Adenosine | 58-61-7 ib

Adenosine, nucleoside muaj li ntawm adenine thiab ribose, muaj ntau yam kev siv tseem ceeb hauv cov tshuaj thiab lub cev vim nws lub cev muaj zog rau ntau lub cev hauv lub cev.

Tshuaj kho mob plawv:

Diagnostic Tool: Adenosine yog siv los ua tus neeg saib xyuas kev ntxhov siab thaum lub sij hawm kuaj mob plawv, xws li myocardial perfusion imaging. Nws pab ntsuas cov kab mob coronary artery los ntawm inducing coronary vasodilation, ua raws li cov teebmeem ntawm kev tawm dag zog lub cev.

Kev Kho Mob ntawm Supraventricular Tachycardia (SVT): Adenosine yog thawj kab tshuaj rau kev txiav SVT ntu. Nws ua haujlwm los ntawm kev ua kom qeeb qeeb los ntawm qhov atrioventricular node, cuam tshuam txoj hauv kev rov qab ua lub luag haujlwm rau SVT.

Neurology:

Tswj qaug dab peg: Adenosine yog ib qho endogenous anticonvulsant nyob rau hauv lub hlwb. Modulating adenosine receptors tuaj yeem muaj cov nyhuv antiepileptic, thiab cov tshuaj adenosine tso tawm tau raug tshawb xyuas raws li kev kho mob rau qaug dab peg.

Neuroprotection: Adenosine receptors ua lub luag haujlwm hauv kev tiv thaiv neurons los ntawm kev raug mob ischemic thiab oxidative kev nyuaj siab. Kev tshawb fawb tshawb nrhiav adenosine lub peev xwm ua tus neeg saib xyuas neuroprotective hauv mob stroke thiab neurodegenerative kab mob xws li Parkinson's thiab Alzheimer's.

Tshuaj ua pa:

Bronchodilation: Adenosine ua raws li bronchodilator thiab yog siv rau hauv kev kuaj bronchoprovocation los kuaj mob hawb pob. Nws ua rau bronchoconstriction nyob rau hauv cov tib neeg uas muaj mob hawb pob, pab txheeb xyuas cov hlab ntsha hyperreactivity.

Antiarrhythmic Properties:

Adenosine tuaj yeem cuam tshuam qee yam ntawm arrhythmias los ntawm kev hloov hluav taws xob hauv lub plawv, tshwj xeeb tshaj yog nyob rau hauv atria thiab atrioventricular node. Nws luv luv ib nrab-lub neej txwv cov teebmeem.

Cov cuab yeej tshawb fawb:

Adenosine thiab nws cov analogues tau siv dav hauv kev tshawb fawb los kawm txog lub luag haujlwm ntawm adenosine receptors nyob rau hauv ntau yam physiological thiab pathological txheej txheem. Lawv pab elucidate adenosine cov dej num hauv neurotransmission, tiv thaiv kab mob, o, thiab kab mob plawv.

Muaj peev xwm kho tau daim ntawv thov:

Adenosine-raws li tshuaj tau raug tshawb xyuas rau cov kev siv tshuaj kho mob hauv cov mob xws li mob qog noj ntshav, kev raug mob ischemic, kev tswj qhov mob, thiab cov kab mob inflammatory. Adenosine receptor agonists thiab antagonists yog cov sib txuas hauv kev kawm.