Fludarabine | 21679-14-1

Fludarabine yog ib hom tshuaj khomob feem ntau siv los kho qee hom qog noj ntshav, tshwj xeeb tshaj yog hematological malignancies. Nov yog ib qho kev piav qhia:

Mechanism of Action: Fludarabine yog ib qho nucleoside analog uas cuam tshuam nrog kev sib txuas ntawm DNA thiab RNA. Nws inhibits DNA polymerase, DNA primase, thiab DNA ligase enzymes, ua rau DNA strand breakage thiab inhibition ntawm DNA kho mechanisms. Qhov kev cuam tshuam ntawm DNA synthesis thaum kawg ua rau apoptosis (programmed cell tuag) hauv cov cell faib sai, nrog rau cov qog nqaij hlav cancer.

Cov Lus Qhia: Fludarabine feem ntau yog siv los kho cov kab mob lymphocytic leukemia (CLL), nrog rau lwm yam kab mob hematological malignancies xws li indolent non-Hodgkin lymphoma thiab mantle cell lymphoma. Nws kuj tseem siv tau rau qee qhov mob myeloid leukemia (AML).

Kev tswj hwm: Fludarabine feem ntau yog muab tso rau hauv txoj hlab ntshav (IV) hauv qhov chaw kho mob, txawm hais tias nws kuj tuaj yeem muab qhov ncauj rau qee kis. Qhov ntau npaum li cas thiab lub sijhawm ntawm kev tswj hwm yog nyob ntawm seb cov qog nqaij hlav tshwj xeeb raug kho, nrog rau tus neeg mob tag nrho cov kev noj qab haus huv thiab cov lus teb rau kev kho mob.

Cov teebmeem tsis zoo: Feem ntau cov kev mob tshwm sim ntawm fludarabine muaj xws li cov pob txha pob txha (ua rau neutropenia, anemia, thiab thrombocytopenia), xeev siab, ntuav, raws plab, ua npaws, qaug zog, thiab ua rau muaj kev kis kab mob. Nws kuj tuaj yeem ua rau muaj kev cuam tshuam loj dua xws li neurotoxicity, hepatotoxicity, thiab pulmonary toxicity hauv qee kis.

Kev ceev faj: Fludarabine yog contraindicated nyob rau hauv cov neeg mob uas muaj pob txha pob txha loj heev los yog lub raum tsis ua hauj lwm. Nws yuav tsum tau siv nrog ceev faj rau cov neeg mob uas muaj lub siab ua ntej lossis raum kab mob, nrog rau cov poj niam cev xeeb tub los yog pub niam mis vim muaj peev xwm ua rau muaj kev phom sij rau tus menyuam hauv plab los yog menyuam mos.

Kev Sib Tham Tshuaj: Fludarabine tuaj yeem cuam tshuam nrog lwm cov tshuaj, tshwj xeeb yog cov uas cuam tshuam rau cov pob txha ua haujlwm lossis lub raum ua haujlwm. Nws yog ib qho tseem ceeb rau cov kws kho mob los tshuaj xyuas tus neeg mob cov npe tshuaj kom zoo thiab saib xyuas cov tshuaj muaj peev xwm sib cuam tshuam.

Kev saib xyuas: Kev saib xyuas cov ntshav tsis tu ncua thiab lub raum ua haujlwm yog qhov tseem ceeb thaum kho nrog fludarabine txhawm rau txheeb xyuas cov tsos mob ntawm cov pob txha pob txha los yog lwm yam kev phiv. Kev kho koob tshuaj yuav tsim nyog raws li cov kev soj ntsuam xyuas no.