Tacrolimus | 104987-11-3

Tacrolimus, tseem paub los ntawm nws lub npe lag luam Prograf ntawm lwm tus, yog cov tshuaj muaj zog tiv thaiv kab mob siv feem ntau hauv kev hloov pauv hauv nruab nrog cev los tiv thaiv kev tsis lees paub.

Mechanism of Action: Tacrolimus ua haujlwm los ntawm inhibiting calcineurin, ib qho protein phosphatase uas ua lub luag haujlwm tseem ceeb hauv kev ua kom T-lymphocytes, uas yog lub cev tiv thaiv kab mob koom nrog hauv kev tsis lees txais cov khoom noj. Los ntawm inhibiting calcineurin, tacrolimus blocks zus tau tej cov pro-inflammatory cytokines thiab tiv thaiv lub activation ntawm T-hlwb, yog li suppressing lub cev tiv thaiv kab mob tiv thaiv lub cev hloov.

Indications: Tacrolimus yog qhia rau prophylaxis ntawm lub cev rejection nyob rau hauv cov neeg mob tau txais allogeneic daim siab, raum, los yog lub plawv hloov. Nws feem ntau siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob xws li corticosteroids thiab mycophenolate mofetil.

Kev tswj hwm: Tacrolimus feem ntau yog siv los ntawm qhov ncauj hauv daim ntawv tshuaj ntsiav lossis tshuaj hauv qhov ncauj. Nws kuj tseem yuav tau txhaj tshuaj intravenously hauv qee qhov xwm txheej kho mob, xws li thaum lub sijhawm hloov pauv tam sim ntawd.

Kev saib xyuas: Vim nws qhov ntsuas qhov ntsuas nqaim thiab qhov sib txawv ntawm qhov nqus, tacrolimus yuav tsum tau ceev faj saib xyuas cov ntshav kom ntseeg tau tias kev kho tau zoo thaum txo qis kev pheej hmoo ntawm toxicity. Kev saib xyuas cov tshuaj kho mob suav nrog kev ntsuas cov ntshav tacrolimus tsis tu ncua thiab hloov cov koob tshuaj raws li qib no.

Cov teebmeem tsis zoo: Cov kev mob tshwm sim ntawm tacrolimus muaj xws li nephrotoxicity, neurotoxicity, kub siab, hyperglycemia, mob plab zom mov, thiab ua rau muaj kab mob ntau ntxiv. Kev siv ntev ntev ntawm tacrolimus kuj tseem tuaj yeem ua rau muaj kev pheej hmoo ntawm kev tsim cov qog nqaij hlav, tshwj xeeb yog mob qog noj ntshav thiab lymphoma.

Kev Sib Tham Txog Tshuaj: Tacrolimus yog metabolized feem ntau los ntawm cytochrome P450 enzyme system, tshwj xeeb tshaj yog CYP3A4 thiab CYP3A5. Yog li, cov tshuaj uas ntxias lossis inhibit cov enzymes no tuaj yeem cuam tshuam rau qib tacrolimus hauv lub cev, uas ua rau muaj kev kho tsis ua haujlwm lossis toxicity.

Kev txiav txim siab tshwj xeeb: Kev siv tshuaj tacrolimus yuav tsum tau ua tus kheej raws li cov xwm txheej xws li hnub nyoog tus neeg mob, lub cev hnyav, lub raum ua haujlwm, cov tshuaj sib xyaw ua ke, thiab muaj cov kab mob sib kis. Kev soj ntsuam ze thiab ua raws li cov kws kho mob tsis tu ncua yog qhov tseem ceeb rau kev kho kom zoo dua qub thiab txo cov kev tsis zoo.