Uridine | 58-96-8 : kuv

Uridine yog pyrimidine nucleoside uas ua haujlwm tseem ceeb hauv tsev thaiv rau RNA (ribonucleic acid), yog ib qho ntawm ob hom nucleic acids tseem ceeb rau kev khaws cia thiab xa cov ntaub ntawv genetic hauv hlwb.

Chemical Structure: Uridine muaj pyrimidine puag uracil txuas rau tsib-carbon qab zib ribose ntawm β-N1-glycosidic daim ntawv cog lus.

Lub luag haujlwm Biological:

RNA Lub Tsev Block: Uridine yog ib qho tseem ceeb ntawm RNA, uas nws tsim cov pob txha ntawm RNA molecules nrog rau lwm cov nucleosides xws li adenosine, guanosine, thiab cytidine.

Neeg xa xov liaison RNA (mRNA): Hauv mRNA, uridine residues encode genetic ntaub ntawv thaum transcription, nqa cov lus qhia los ntawm DNA mus rau cov protein synthesis machinery nyob rau hauv lub cell.

Hloov RNA (tRNA): Uridine kuj tseem muaj intRNA molecules, qhov uas nws koom nrog hauv cov txheej txheem txhais lus los ntawm kev paub txog cov codons tshwj xeeb thiab xa cov amino acids sib thooj rau ribosome.

Metabolism: Uridine tuaj yeem ua ke de novo hauv hlwb lossis tau los ntawm cov khoom noj. Nws yog tsim los ntawm kev hloov pauv enzymatic ntawm orotidine monophosphate (OMP) lossis uridine monophosphate (UMP) hauv txoj kev pyrimidine biosynthesis.

Physiological tseem ceeb:

Neurotransmitter Precursor: Uridine plays lub luag haujlwm hauv lub hlwb ua haujlwm thiab kev loj hlob. Nws yog ib qho precursor rau cov synthesis ntawm lub hlwb phospholipids, nrog rau phosphatidylcholine, uas yog ib qho tseem ceeb rau neuronal membrane kev ncaj ncees thiab neurotransmitter signaling.

Neuroprotective Effects: Uridine tau kawm txog nws cov peev xwm neuroprotective thiab nws lub peev xwm los txhim kho synaptic muaj nuj nqi thiab neuronal plasticity.

Therapeutic Potential:

Uridine thiab nws cov derivatives tau raug tshawb xyuas rau cov kev siv tshuaj kho mob hauv cov kab mob neurological, suav nrog Alzheimer's kab mob thiab kev puas siab puas ntsws.

Uridine supplementation tau tshawb nrhiav los ua ib lub tswv yim los txhawb kev paub txog kev ua haujlwm thiab txo cov tsos mob cuam tshuam nrog cov kab mob neurodegenerative.

Khoom noj khoom haus: Uridine muaj nyob hauv ntau yam khoom noj, suav nrog nqaij, ntses, zaub, thiab khoom noj siv mis.