L-Tyrosine |60-18-4 ib
Khoom Description
Tyrosine (abbreviated li Tyr los yog Y) los yog 4-hydroxyphenylalanine, yog ib qho ntawm 22 amino acids uas siv los ntawm cov hlwb los tsim cov proteins.Its codonsare UAC and UAU.Nws yog ib qho tsis tseem ceeb amino acid nrog ib pawg polar sab.Lo lus "tyrosine" yog los ntawm Greek tyros, lub ntsiab lus cheese, raws li nws tau pom thawj zaug hauv xyoo 1846 los ntawm German chemist Justus von Liebig hauv cov proteincasein los ntawm cheese.Nws yog hu ua tyrosyl thaum raug xa mus rau raws li ib tug functional groupor side chain.yrosine yog ib tug precursor rau neurotransmitters thiab tsub kom plasmaneurotransmitter ntau ntau (tshwj xeeb yog DOPAM thiab norepinephrine) tab sis tsis tshua muaj kev cuam tshuam rau mus ob peb vas.Qhov cuam tshuam rau lub siab xav pom ntau dua nyob rau hauv tib neeg raug kev ntxhov siab.
Ib cag los ntawm kev ua cov proteinogenic aminoacid, tyrosine muaj lub luag haujlwm tshwj xeeb los ntawm kev tsim txiaj ntawm phenol functionality.Itoccurs nyob rau hauv cov proteins uas yog ib feem ntawm cov teeb liab transduction txheej txheem.Nws ua haujlwm ua tus txais ntawm phosphate pawg uas tau pauv los ntawm txoj kev ntawm cov proteinkinases (hu ua receptor tyrosine kinases).Phosphorylation ntawm hydroxylgroup hloov cov kev ua ntawm lub hom phiaj protein.
Ib qho tyrosine residue kuj ua lub luag haujlwm tseem ceeb hauv photosynthesis.Hauv chloroplasts (photosystem II), nws ua raws li anelectron pub rau hauv kev txo cov oxidized chlorophyll.Nyob rau hauv cov txheej txheem no, nws undergoes deprotonation ntawm nws phenolic OH-group.Cov radical no tau raug txo qis hauv photosystem II los ntawm plaub pawg manganese pawg.
Ntau cov kev tshawb fawb tau pom tias tyrosine yuav pab tau thaum muaj kev ntxhov siab, txias, qaug zog, poob ntawm ib tug neeg hlub xws li kev tuag los yog kev sib nrauj, kev ua hauj lwm ntev thiab pw tsaug zog, nrog kev txo qis hauv kev ntxhov siab cov tshuaj hormones, txo cov kev ntxhov siab vim poob phaus pom hauv tsiaj sim, txhim kho kev txawj ntse thiab lub cev kev ua tau zoo pom nyob rau hauv humantrials;Txawm li cas los xij, vim hais tias tyrosine hydroxylase yog tus nqi-txhim enzyme, qhov cuam tshuam tsawg dua li L-DOPA.
Tyrosine tsis zoo li muaj kev cuam tshuam loj rau lub siab, kev txawj ntse lossis kev ua haujlwm ntawm lub cev hauv ib txwm muaj.Ib koob tshuaj txhua hnub rau kev soj ntsuam kuaj pom hauv cov ntaub ntawv yog kwv yees li 100 mg / kg rau tus neeg laus, uas yog kwv yees li 6.8 grams ntawm 150 lbs.Cov koob tshuaj ib txwm muaj rau 500-1500 mg ib hnub twg (cov koob tshuaj pom zoo los ntawm cov tuam txhab feem ntau; feem ntau yog sib npaug rau 1-3 tsiav tshuaj ntawm ntshiab tyrosine).Nws tsis pom zoo kom tshaj 12000 mg (12 g) ib hnub.
Specification
| Cov khoom | Txuj | Cov qhabnias xeem |
| Specific Rotation[a]ᴅ²⁰ | -9.8 ° rau 11.2 ° | -10.4° Nws |
| Chloride (CI) | Tsis ntau tshaj 0.05% | ＜0.05% |
| Sulphate (SO₄) | Tsis ntau tshaj 0.04% | ＜0.04% |
| Hlau(Fe) | Tsis ntau tshaj 0.003% | ＜0.003% |
| Cov hlau hnyav | Tsis ntau tshaj 0.00015% | ＜0.00015% |
| Poob rau ziab | Tsis ntau tshaj 0.3% | ＜0.3% |
| Residue ntawm Ignition | Tsis ntau tshaj 0.4% | ＜0.4% |
| Assay | 98.5% -101.5% | 99.3% |
| Xaus | Ua raws li USP32 tus qauv | |
